Project Details

Calculates the ratio of nonsynonymous (Ka) to synonymous (Ks) nucleotide substitution rates inorder to indicate selective pressures on genes, and can also be used to identify pairwise combinations of genes or branches of gene phylogenetic trees, where encoded proteins may have changed function. This calculator implements the following algorithms: NG (Jukes Cantor Models), LWL (JC-K2P-K2P) and MLWL (K2P-K2P-K2P).

This web-based application was implemented by following the calculations specified in this scientific paper :
| Zhang Zhang, Jun Li, Xiao-Qian Zhao, Jun Wang, Gane Ka-Shu Wong, Jun Yu, KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging, Genomics, Proteomics & Bioinformatics, Volume 4, Issue 4, 2006, Pages 259-263, ISSN 1672-0229, DOI: 10.1016/S1672-0229(07)60007-2.